Anti-Integrin Therapy-Free-Samples for Students-Myassignmenthelp

Question: Talk about abou the Anti-integrin treatment to hose Inflammation and diminish scar development. Answer: Hostile to integrin treatment is as a rule broadly utilized by the researchers and the analysts by and by. It is being utilized in rewarding a few kinds of sicknesses, for example, malignant growth and help in the endurance of individuals. Integrin proteins communicated on both endothelial and tumor cells and subsequently it helps in principally three exercises, for example, antiangiogenesis; against intrusion; and hostile to tumor.Anti-integrin treatment is likewise utilized in restoring people experiencing including various sclerosis, incendiary entrail illness, and psoriasis. Alpha4beta1 (exceptionally late antigen-4) and alphaLbeta2 (leucocyte work related antigen-1) integrins have significant jobs in other resistant procedures, for example, including the arrangement of the invulnerable neurotransmitter and the separation of T partner 1 lymphocytes.It is agonizing for the people who experience the ill effects of scarring in abundance that outcomes from coming about because of con sumes, singes and a few other injuries.It prompts both truly and mental impacts in them.Presently we don't have any authorized medications that forestall or lessen the development of scar.Inflammation assumes a huge job in the typical of wound recuperating process.It has been seen that it doesn't expect contamination to happen. Be that as it may, if the irritation is delayed, it doesn't prompt the recuperating of wound (Mosli, Rivera-Nieves and Feagan 2014). Aggravation in abundance assumes a noteworthy job in the development of scar where the degree of irritation in an intense injury will decide the degree to which fibrosis and scarring would happen. It has been seen through a few exploration tests that ominous impacts of fix in the tissues including fibrosis and the arrangement of scar happens due irritation that is related with macrophages. As indicated by the trials, wounds that don't have or have low quantities of macrophages have encountered diminished fibrosis and scarring when contrasted with wild-type mice.Targeted consumption of macrophages during the early incendiary stage (days 0-5) of recuperating brought about scarring to a base level in a mouse model.According to these outcomes it very well may be recommended that lessening the quantities of macrophages and early irritation (day 2-5) might decrease the development of scars. Macrophages are safe cells that assume a noteworthy job in directing the development of scars. They enter the injury as a monocyte 2 days after the injury occurs.There are a couple of proteins known as surface integrins that assume a significant job for the relocation of monocytes into locales of irritation and injury. Integrins are grip receptors and comprise of two subunits, that help in interceding the cell-cell and cell-framework collaborations. These collaborations are significant for the grip and relocation of the cell. There are various kinds of integrins and are communicated in an alternate way. Integrins, for example, D2, M2, Xto, L2 and E7 are explicit two leukocytes. Integrins go about as magnificent remedial focuses since their ligand-restricting space is presented to the extracellular milieu and they can be repressed through pharmacological means.There are sure ailments which can be treated in a successful way by utilizing authorized enemy of integrin treatments that target integrins that are explicit to resistance. They are utilized adequately in clinical settings to treat illnesses in which irritation assumes a huge job in the movement of disease.As the incendiary procedures assume an essential job in the mending of wounds and hostile to integrin treatments have been fruitful in lessening aggravation in different maladies, it is suggested that enemy of integrin treatment will decrease irritation and in this manner improve the arrangement of scars. Tumor corruption factor-(TNF-) is a proinflammatory cytokine that is created by macrophages, and by renal mesangial and cylindrical epithelial cells. It assumes a vital job in invigorating the arrival of interleukin (IL)- 1, monocyte chemoattractant protein-1 (MCP-1), and changing development factor-(TGF-). Blockage of TNF-is by and by utilized in the treatment of a few immune system incendiary maladies in the wake of being investigated generally in clinical labs. It was speculated that blocking TNF-with a monoclonal immunizer would help in forestalling irritation and renal fibrosis in crescentic glomerulonephritis. Therefore, the target of this investigation is to decide if blocking explicit monocyte integrins lessens aggravation and improves scarring results in a consume mouse model. We have built up a novel remedial monoclonal immune response named Scarless. In this examination we will test the productivity and instruments of Scarless to lessen monocyte relocation into consumes wo und tissue. Moral Considerations Lab creatures ought to be furnished with compassionate consideration and solid conditions during their stay in the creature place of the lab or the institution.The rodents utilized for the test ought to be given appropriate food and diet and they ought not be hurt or tormented in any way. All the moral standards ought to be trailed by the specialists while leading the test and the individuals from the moral council should keep a mind the methods that are being followed. The offices of lodging the creatures in the research center should meet or surpass ebb and flow guidelines and rules and ought to be assessed twice a year.There ought to be experienced clinicians , veterinary specialists and their aides should keep a beware of the conduct of the creatures who are thought about for the trial. They should keep a check and know about the contrasts between unordinary practices and the normal.They ought to survey them in an appropriate way and give treatment of medical issues whenever requ ired. Trial controls Two gatherings of rodents are taken for the investigation and one of them goes about as the control to look at the outcomes toward the finish of the examination. Gear required Materials of Immuno histochemistry, for example, slides, paraffin areas and stains Approach Counter acting agent bar of TNF-a decreases aggravation and scarring .Male rodents of weight between 200 to 250 grams and age between 6 two months ought to be taken .They ought to be given appropriate eating routine and water (Schulz et al.2015)A blocking IgG2a monoclonal immune response to rodent TNFa (C432) ought to be utilized in the analysis. Immunohistochemistry and Immunofluorosence strategy is to be utilized in the methodology. The monoclonal antibodies that are explicit for rodent monocytes or macrophages should utilized while directing the examination. Nephrotoxic nephritis was instigated in rodents by intravenous infusion of bunny antirat glomerular storm cellar film (GBM) nephrotoxic serum (NTS). Hostile to TNF-monoclonal counter acting agent or saline was given by intraperitoneal means and three times each week in four conventions: explore 1, days 0 to 7; analyze 2, days 0 to 14 and days 4 to 14; test 3, days 4 to 28; and test 4, days 14 to 28. Results In the analysis 1, rodents that were treated from sickness enlistment had less glomerular fibrinoid corruption and less glomerular macrophages at day 7. In the examination 2, rodents rewarded from day 0 or day 4 demonstrated an improvement in the renal capacity, as saw by serum creatinine, with a noteworthy decrease in crescents.In test 3, hostile to TNF-treatment diminished pee protein to creatinine proportion and urinary MCP-1 levels by a huge sum. Serum creatinine was protected at both the days 14 and day 28. Tubulointerstitial irritation, glomerular and tubulointerstitial scarring, and markers of fibrosis [-smooth muscle actin (- SMA) and type IV collagen] were less in rewarded rodents at day 28 out of a huge way. In the analysis 4, serum creatinine was more prominent and tubulointerstitial scarring was lower in postponed rewarded creatures. End At the point when the endogenous TNF-is killed it prompts a decrease in aggravation in the glomerulus, development of sickle, and tubulointerstitial scarring, with protection of renal capacity, in exploratory crescentic glomerulonephritis. Barricade of TNF-is successful in any event, when it is presented at the hour of most extreme glomerular inflammation.After the investigation, it very well may be presumed that blocking TNF-a forestalls provocative reaction in mouse model (Berghe et al.2014 ). References Berghe, T.V., Linkermann, A., Jouan-Lanhouet, S., Walczak, H. what's more, Vandenabeele, P., 2014. Directed putrefaction: the extending system of non-apoptotic cell passing pathways.Nature surveys. Sub-atomic cell biology,15(2), p.135. Freeman, S.A., Goyette, J., Furuya, W., Woods, E.C., Bertozzi, C.R., Bergmeier, W., Hinz, B., Van Der Merwe, P.A., Das, R. what's more, Grinstein, S., 2016. Integrins structure an extending diffusional hindrance that arranges phagocytosis.Cell,164(1), pp.128-140. Ley, K., Rivera-Nieves, J., Sandborn, W.J. what's more, Shattil, S., 2016. Integrin-based therapeutics: organic premise, clinical use and new drugs.Nature audits. Medication discovery,15(3), p.173. Mosli, M.H., Rivera-Nieves, J. also, Feagan, B.G., 2014. Lymphocyte dealing and against grip systems in provocative inside infection: current and future prospects.Drugs,74(3), pp.297-311. Schulz, J.N., Zeltz, C., Srensen, I.W., Barczyk, M., Carracedo, S., Hallinger, R., Niehoff, An., Eckes, B. what's more, Gullberg, D., 2015. Decreased granulation tissue and twisted quality without 111 integrin.Journal of Investigative Dermatology,135(5), pp.1435-1444. Wynn, T.A., Chawla, A. what's more, Pollard, J.W., 2013. Starting points and Hallmarks of macrophages: improvement, homeostasis, and disease.Nature,496(7446), p.445.

Victorian Poems Essay Example For Students

Victorian Poems Essay The Victorian time frame was a period of radical change. Gone were the Romantic discharges from hopelessness where winged creatures would sing like a rose embowered (To a Skylark) and in was the Origin of Species which shook the strict world and tremendous mainstream changes, for example, the modern upset. While a few people grasped these disclosures with reestablished eagerness, others began the way towards existentialism. Subsequently, the sonnets which I will examine are Dover Beech by Mathew Arnold and Gods Grandeur by Gerald Manly Hopkins which manages such issues yet brings about various ends. Interestingly, the two sonnets are intriguing from the initial refrain, Dover sea shore starts of quiet as the grinding thunder of the ocean ebbs the scene among the sparkles of moon light. The lexis is moderately straightforward as Arnold shrewdly utilizes monosyllables alongside basic action words: on the French coast the light sparkles and is gone to make a mitigating feeling. Be that as it may, this rhythm doesn't make edification however rather an everlasting note of misery! On the other hand, Gods magnificence has a higher opening rhythm as Hopkins utilizes a progression of clear symbolism to depict the world. The normal world is accused of the liveliness of power and loaded up with the extravagance of overflowing oil; Hopkins is depicting the world as wondrous spot however in the second quatrain he inquires as to whether there is so much ever-present magnificence: Crushed. For what reason do men then now not reck his bar? This sentence reinforces desperation as the inquiry contains a few focused on syllables. In like manner, Hopkins the notoriety of have trod, have trod, have trod represented the movement of time where inside rhyme in line 8: And everything is burned with exchange; obscured, spread with work represents the mayhem which the world has now debased into. From an idealistic world in the initial quatrain, through keeps an eye on demolition (fundamentally the modern upset), men has overseen distance himself from nature. As should be obvious, change has various impacts of various individuals. In this occurrence, Hopkins doesn't share the excitement of the modern transformation and is rather progressively worried about the skeptical nature of the world. In the second refrain of Dover Beach, we discover increasingly about the creators pity in the northern ocean. He uncovers that back and forth movement of the ocean helps him to remember human wretchedness simply like Sophocles some time in the past. This skeptical view on life is the absolute opposite of such Romantic sonnets by Keats and is predominately brought about by the sentiment of abandonment and absence of expectation.

Advancements in Medical Research Due to Hela Cells Free Essays

Katrina Samborski Honors English 1100 Dr. Nicole Caswell November 10, 2012 Advancement of Medical Research from HeLa Cells HeLa basically represents Henrietta Lacks, a youthful mother in the 1951 who went to the specialist grumbling of vaginal draining and found she had cervical malignancy. Henrietta’s cells were taken for a biopsy and were seen as like nothing at any point seen previously; her cells were unfading. We will compose a custom article test on Headways in Medical Research Due to Hela Cells or on the other hand any comparative subject just for you Request Now Her malignancy cells twofold every 20 to 24 hours and have lived on for as far back as 60 years. Since HeLa cells were made, our universe of present day medication has been totally changed. We now antibodies for once serious illnesses and have utilized the cells for cloning and other biomedical research. Despite the fact that the cells have done a lot of good, they have additionally made significant mischief Henrietta Lacks, her family, and potential preliminary research members. Along these lines, however some may think it was morally off-base of Henrietta Lacks’ specialists to not illuminate her that they were utilizing her cells, she is the explanation we have had the option to spare a great many lives. It was at Johns Hopkins Hospital when Dr. Gey, a noticeable disease and infection specialist, found Henrietta’s cells were eternal. Since disease cells will pass on outside the body without the correct blend of synthetic substances, Dr. Gey made the roller tube. This contraption held glass tubes containing tests in supplement rich liquids, turned gradually †in some cases only two insurgencies 60 minutes, presenting the cells to the perfect blend of air and supplements. When Henrietta’s cells were put in this gadget, they divided constantly. While their examination esteem is unchallenged, the tumor cells had made ruin in Henrietta Lacks’ body. Skloot describes the lab specialist Mary Kubicek who was available at the examination. â€Å"The tumors had totally obstructed her urethra, leaving specialists unfit to pass a catheter into her bladder to purge it. Tumors the size of balls had about supplanted her kidneys, bladder, ovaries and uterus. Furthermore, her different organs were so shrouded in little white tumors it looked as though somebody had filled her with pearls† (Williams). Despite the fact that her cells are harmful, HeLa cells share numerous qualities with typical cells, making them valuable in contemplating protein combination, the human genome and how infections work. Dr. Gey offered the cells to scientists around the globe, who utilized them to build up an assortment of prescriptions. HeLa cells were the first to go into space in an unmanned satellite to check whether people could endure zero gravity. â€Å"This cell line is utilized all around the globe and altered cell science since they became so well in culture, said William Earnshaw, chief research individual at the University of Edinburgh’s Center for Cell Biology. â€Å"They yielded an immense measure of information,† Earnshaw said (Sharp). In the mid 1950s, the world encountered the greatest polio pandemic ever. Jonas Salk conceived the world’s first polio antibody, yet testing it would require colossal supplies of live cells that, at that point, would have included the penance of thousands of monkeys. HeLa cells end up being in fact increasingly appropriate for testing, and significantly less costly and muddled, than utilizing monkeys. In addition, HeLa cells developed for all intents and purposes anyplace and on any surface, including while at the same time coasting on fluid. A HeLa large scale manufacturing and appropriation focus was in this manner set up at the Tuskegee Institute, incidentally at the very same time that the scandalous Tuskegee syphilis concentrate on dark subjects was being done. Before long HeLa cells were to empower the main disaggregation of chromosomes, various revelations from hereditary and viral investigations, and the primary ever cloning of a cell, quality mapping, in vitro treatment and a whole lot more. (Ncayiyana) HeLa cells have impacted medication from numerous points of view incorporating with giving us information about the human papillomavirus (HPV) DNA and HPV18-positive. HeLa cells have been connected to changes in microRNA articulation. Since HPV18 has been related with exceptionally forceful adenocarcinomas, this finding may clarify why Dr. Gey was astonished by the productive development of HeLa cells in culture. Routine Papanicolaou smear screening may not recognize quickly dynamic cervical carcinomas; the new HPV immunization holds the guarantee of forestalling these tumors. (Hutchins). The issue of conceivable pollution of other long haul refined tumor cell lines with HeLa cells caused a worldwide shame, yet additionally raised the worry of misattributing a particular property so another cell line, for instance, an infection or a tumor-explicit marker, which really has a place with HeLa. With the proceeded and developing utilization of tissue culture in organic chemist examine, intra-and interspecific sullying turns into a noteworthy hazard. The assurance of stable hereditary markers on refined cells is an amazing asset for checking such pollution. Late investigations in which refined cells and incalculable clones of physical cell half breeds have been utilized for hereditary examination have indicated that, with the correct utilization of polymorphic markers to portray the cells, the chance of undetected cross sullying of societies is not, at this point the difficult it once may have been. Along these lines, with an end goal to explain the attributes of the HeLa cell and set up its plausible genotype for better-known polymorphisms, we contemplated HLA and different markers, in the enduring spouse and offspring of Henrietta Lacks. (Hsu) Not just were there a few negative impacts for Henrietta Lacks, yet the overall population has discovered imperfections with HeLa cells too. The Drug Information Association supported a workshop that united individuals who manage encouraging or controlling the assortment of clinical examples for hereditary examinations to supplement tranquilize preliminaries. Hereditary investigations of clinical examples have for a considerable length of time needed to arrange a dubious way through educated assent, privacy, and administrative oversight, yet as indicated by two or three speakers who noticed the Henrietta Lacks story, the 19 months since the book’s distribution have made a few people much progressively careful about this examination. â€Å"I think it was unsettling to individuals who are not used to contemplating how examples are dealt with, that their examples could outlast them,† said the meeting’s primary coordinator and seat, Amelia Wall Warner, Ph. D. who heads clinical pharmacogenomics and clinical example the board for the medication organization Merck. The Skloot book is by all accounts making a ton of discussion, with patients frequently requesting a menu of assent that enormous scope preliminaries with a huge number of patients can’t oblige, she noted. (Zoler) Although there are allegations against spe cialists and organizations that purchased these cells expressing they did as such without Henrietta Lacks’ assent, we owe our universe of present day medication to her. Her cells permitted us to research and investigation innumerable sicknesses and made the way for find out about the human enome and disease cells. Dr. Gey stated, â€Å"It was the best of times, it was the most exceedingly awful of times. † It was the best of times for science in this exceptionally unconventional tumor offered ascend to the HeLa cell line, which has been accessible for the different investigations alluded to by others. For Mrs. Needs and the family she deserted, it was the most noticeably awful of times. Logical advancement and without a doubt progress of different sorts is frequently made at incredible cost, for example, the penance made by Henrietta Lacks† (Jones). While her family presently can't seem to be redressed, HeLa cells keep on being utilized regularly in the clinical field. Works Cited: Ncayiyana, Daniel J. â€Å"The phenomenal story of the eternal life of Henrietta Lacks. †Ã‚ South African Medical Journalâ 101. 3 (2011): 141. Wellbeing Reference Center Academic. Web. 12 Nov. 2012. Grover M. Hutchins, Brendan P. Lucey, and Walter A. Nelson-Rees. Chronicles of Pathology Laboratory Medicine. 133. 9 (Sept. 2009)â p1463. Word Count: 4083. Jones HW Jr â€Â Am J Obstet Gynecolâ †01-JUN-1997; 176(6): S227-8 MEDLINE ® is the hotspot for the reference and conceptual of this recordâ Susan H. Hsu, Bernice Z. Schacter, Nancy L. Delaney, Thomas B. Mill operator, Victor A. McKusick, R. H. Kennett, J. G. Bodmer, D. Youthful and W. F. Bodmer Scienceâ , New Series, Vol. 191, No. 4225 (Jan. 30, 1976), pp. 392-394 Published by: American Association for the Advancement of Science Article Stable URL: http://www. jstor. organization/stable/1741942 Mitchel Zoler. Interior Medicine News. 44. 17 (Oct. 15, 2011)â p63. Word Count: 433. Williams, Nigel. â€Å"Prize For the HeLa Cell Story. †Ã‚ Current Biologyâ 20. 23 (2010): n. ag. Sciverse. com. Web. 11 Nov. 2012. Manfuso, Jamie, and Stephanie Desmon. â€Å"Honoring the Henrietta Lacks Legacy at Hopkins. †Ã‚ Hopkins Medicine Magazine. Johns Hopkins, 20 May 2011. Web. 11 Nov. 2012. Hepworth, Jeri, PhD. â€Å"Advocacy for Henrietta Lacks and Family Medicine. † Editorial. Family Medicine Sept. 2011: 595-96. Society of Teachers of Family Medicine. Web. 11 Nov. 2012. Sharp, Rob. Life and eternity of a ladies who will live for ever. The Independent. November 10 2010. Web. Nov 12 2012. Step by step instructions to refer to Advancements in Medical Research Due to Hela Cells, Essays

The Death Penalty For Perry Smith and Dick Hickock - Free Essay Example

The death penalty for both Perry Smith and Dick Hickock was for the best. Having them dead meant peace to the public and justice for their crime. They have carried out other offenses in their time such as check fraud and theft. Though they were both wounded in accidents they were still sane enough to know they were in the wrong. As for the series of events that involved the Clutters, Hickock and Smith planned out the burglary and even added no witnesses. They are a dangerous and needed to be hung, especially since the only other choice is 15 years in prison with parole. Having them out and about will only fuel the communitys fear of not knowing if they could be the next to go. No matter how its looked at, Hickock and Smith are a threat and a danger to the public. They did not just commit simple burglary and check frauds, but also perpetrated capital murder. At one point they planned to rob another victim, Mr. Bells, of his belongings and his life. If they can go and execute another citizen then there is proof that they will not do it again. This unpredictability will make it hard for pedestrians to live safely when Hickock and Smith are on the loose. There is probability of Hickock and Smith to commit another crime, or even another murder, and even possibly be able to get away with it. 15 years in prison will not completely change their way of thinking, there is a possibility that it will but it could also let them see where they messed up. The death penalty was necessary for Hickock and Smith because their mental state was competent enough to stand trial, they would most likely be tempted to escape, and they had a high chance of being rearrested. Hickock and Smith were competent enough to be able to stand trial according to psychologist. Disregarding the fact that he said that there was a chance that Smith might be insane, at the time of the murder Smith seemed to be very conscious of what he was doing. He knew it was wrong to let Hickock rape Nancy Clutter and to kill the Clutters that were in the house at the time. Hickock, on the other hand, was the one that planned the robbery and the one that said to leave no witnesses. It was also his idea to rob and kill Mr. Bells before they got to their next destination. He knew exactly what he was going to do even before he stepped in to the Clutters house and he was even persistent when they could not find the safe that was said to be there. They showed signs of being sane from what was told and as Dwane West said that if they knew right from wrong then they had to be competent. If Hickock and Smith were to have gotten the life sentence instead of the death penalty, once they get paroled then the police would have to keep a close eye on them. The reason for this is that there is high chance of criminal that is released from prison to get rearrested in a span of 3 years. There is a higher chance for those convicts to be rearrested in an extent of 5 years and Hickock and Smith are no different. After they were arrested the first time, they went on and kept on doing fraud checks, petty theft and then burglary which then led to capital murder. With this alone, it shows that letting Hickock and Smith be paroled would not be that should be done because it would put the public in danger again. Many people lived in fear when Hickock and Smith were on the run, it also caused distrust between the citizens of Holcomb. If the so called life sentence was extended and used without parole then that would be the better choice but there is still the chance of them trying to escape. Smith tried to break out by attempting to have some random individuals help him, which of course failed in the end. Consequently, there is no way to escape the punishment for capital murder unless they were wrongly accused, which they were not. All of the evidence is there, from the boot that made the footprint pattern to the murder weapon that was used to kill the Clutters. They got a fair trial and even if they didnt, the outcome would most likely not be any different especially since the detectives had enough proof to sentence them to jail three times over. Hickock and Smith already knew that there would be no way to change their punishment once they got caught, Smith even went as far as to say that he was not going to apologize to the family. Smith knew that he could not change anything with an apology, the law is the law there is no way to overlook it for a couple of convicts. Even if it was morally wrong to hang them, the jury had the last word and once decided there was no going back. It all came down to the lives of two murders who killed for what seems to be no reason, or the health and s afety of Holcombs community. There was only one way to protect the public from Hickock and Smith whilst still getting justice for the crime.

Foregrounding of Feminism in A Good Man is Hard to Find Essay

Foregrounding of Feminism in â€Å"A Good Man is Hard to Find, by Flannery OConnor â€Å"A Good Man is Hard to Find, by Flannery OConnor, shows a family trip to Florida which end to an unexpected death at the end of the story. In the progression of this story, O’Connor has presented women as naà ¯ve with graceful images. Women are presented as the weaker sex while men are given more importance and powerful roles. In this regard this story can be viewed as feministic point of view. Feminism is self-awareness among women about women’s rights on the base of political, social, and economic equality to men (Thompson 18). Feminist Criticism offers a Unique understanding of Flannery OConnor’s short story A Good Man is Hard to Find because it reflects†¦show more content†¦Even though John Wesley is still a junior, he has no signs of respect for his elderly grandmother and does not consider his elderly grandmother as his same position. John Wesley says, â€Å"if you don’t want to go to Florida, why dontcha stay at home?†( 678). Grandmother, being a head of the family has no power to decide for where she want to go. Not only John Wesley but also showing disrespect, his father Baiely has no objection to the way John Wesley shows disrespect to his mother as Baiely prefer to remain silent. One can infer that John Wesley shows his traditional Patriarchal male behavior of dominance when grandmother asks him what he would do if Misfit caught him (678). John Wesley replies, â€Å"I’d smack his face† (678). His response clearly indicates masculine response of violence and Stereotypical male behavior. In the context of male stereotypes Dawn Ward and Jack Balswic in their journal, The Pacific Sociological Review under the topic Strong Men and Virtuous Women: A Content Analysis of Sex Roles Stereotype writes, â€Å" Stereotypes of men involve strength and dominance† . In other words, Stereotypes of male is believed to be confident and aggressive where as women are often expected to be passive an d minor than male Although four women are introduced in A Good Man is Hard to Find and all four characters play very important and crucial roles, they remain nameless expect for a child June star. Characters are referred toShow MoreRelatedVoice of Imprisoned Woman in Girish Karnad Nagmandala2301 Words   |  10 PagesScholar Banasthali University Abstract Girish Karnad austmerely scrutinizes the unvoiced mental and physical pain of a woman whose conscious and unconscious mind is conditioned so completely that she sees herself and the world around her only in a way man would like her to see through the play â€Å"Nagmandala†. Starting from the ancient to the modern era, woman is just like clay in the hands of the patriarchal society. The work of woman be underpaid, she is being demolished and her grief is unheard and is

The Effect Of Sensor Market On The Environment Of Rapid...

1) The overview of simulation In recent years, the sensor market is expected to have a great potential for development. This is because under the environment of rapid progress of technology, sensors has been extensively applied in high-tech products with the high frequency of use, such as smart-phones, laptops and other portable equipment. Under the simulated market, the sensor market was carved up by four companies, they are Andrews, Baldwin, Chester and Digby, and each of them also operated 5 different product lines which are traditional, low-end, high-end, performance and size products. In this simulation, our company generally experienced two stages: Stage 1 (round 1-3) Our company was not performed excellently during this stage. The overall market share for our products was in the state of continued to decline (from 25.51% to23.11%) as well as the share price (from $40.36 to $27.54). consequently, this sluggish performance led to the market capitalization decreased from $81 million to $66 million, which is in the third place in the four companies. Stage 2 (round 4-7) Over seven rounds of heated competition, there were several pound achievements we madeï ¼Å¡ i. We not only reached the highest overall market share(40.38%), but also the highest market share for each individual product comparted to the other three rivals. These laid a solid foundation for our strong retail sales. ii. There were totally 4976410 shares being issued by our company and the share price hasShow MoreRelatedEnsuring The Safety Of Harvests Essay1330 Words   |  6 PagesEnsuring the safety of harvests Ensuring that drinks, food, and pharmaceuticals are safe for human consumption is one of the ways by which photonics technologies enhance life. Food quality inspections and food safety have been improved all thanks to the latest innovations in spectral imaging sensors. Direct real-time monitoring and ruggedized in or at-line processing monitoring are now being done at high volumes. 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Dimensions Of Physical And Mental Health †MyAssignmenthelp.com

Question: Discuss about the Dimensions Of Physical And Mental Health. Answer: Overview of Mental Health According to WHO (2014, mental health refers to ones well-being status where they can individually realize their potential, cope with usual stresses in life, productively work and further, contribute to their community. It thus encompasses their psychological, emotional and social well-being. Mental health impacts on ones thinking, feelings and actions. From the definition, it is clear that mental health determines how one handles stress, their relationship with others and their approach to decision making.To enhance the mental health of a population there is need to; carry out health promotion in the society on the importance of mental well-being; prevent mental disorders; prevent violations against human rights and; provide care for those suffering from mental disorders. Mental illnesson the other hand refers to variousmental health conditions including disorders which alter ones mood, their way of thinking and also, their behavior. Mental illnesses include depression, anxiety disorders, schizophrenia, eating disorders, bipolar depression and addictive behaviors (WHO, 2014). Considering Georgias symptoms from the case study, it is clear that she has a social anxiety disorder. Anxiety disorders can be classified into four categories. They include; panic disorder whereby a feeling of terror strikes at random; social anxiety disorder where one has a social phobia; specific phobias and; generalized anxiety disorder (Uher et al, 2013). Given the descriptions, Georgias case includes both social and panic disorders. The two disorders are usually evidenced by symptoms like palpitations, shortness of breath, chest pains, sleep problems and fear (Versella et al, 2016). She experiences these in the event of an assignment or examinations. Various factors including biological factors, life experiences and a family background of mental health problems contribute makes one likely to develop mental illnesses (Gambini, 2016). All humans are genetically vulnerable to developing mental illness which may be triggered by different stress experience levels in ones life. Common triggers for mental disorder include for instance, drug abuse, work-related stress, relationship stress, and cases of traumatic events (Versella et al, 2016). It is evident that Georgias case is similar to that of her mother as they both present with anxiety and the inability to cope with the disorder. The condition is thus genetic in a way considering this similarity in symptoms and signs. The anxiety disorder arises from Georgias stress due to school-related workload. The condition has also made it difficult for her to concentrate in her studies as it presents with panic, worry, a lack of concentration and withdrawal from ones social life. Symptoms and Early Warning Signs Early warning signs of anxiety disorder according to Uher et al (2013) include insomnia; where there the affected individual experiences little or no sleep as it is in Georgias case. She finds it difficult to sleep and also wakes up very exhausted. Another early warning sign of this particular disorder includes the tendency to be often exhausted (Greener, 2014). Thirdly as described in Versella et al (2016), withdrawal from social life and the tendency to want to be in isolation is also a sign of social anxiety disorder. The patient in the case study has not seen her friends for four weeks because she their declines invitation. The social anxiety has also seen her avoid any romantic relationships for about two years (School ofNursing Midwifery, 2017). The feelings of exhaustion particularly make individuals with the social anxiety disorder to be unable to perform daily tasks (Wright et al, 2016). Having been overwhelmed by the workload in her studies, Georgia decides to change from full-time to part-time in the current semester. Difficulty in concentration is also a clear indication of social anxiety disorder. In her studies too, Georgia finds it difficult to concentrate in her class work and inability to complete her assignments. According to Versella et al (2016) anxiety disorder presents with panic and worry. Georgia has been described to be always panicky and worried whenever there is an assignment or an exam indicating that she has the disorder. In addition, individuals with the disorder also present with shortness of breath, increased heart rate and a sense of impending doom (Wright et al, 2016). More warning signs for individuals with anxiety disorder according Asakura (2015) include unusual confusion or anger or fear, severe mood swings, change in eating habits that are had not been nutritionally advised and unexplained pain. The relationship between physical health and mental health Physical health and mental health are both critical determinants of an individuals general health (Shioiri, 2015). Determination of an individuals health and well-being relies on the state of both their mental and physical health. According to the World Health Organization (2014), health is a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity. This definition therefore indicates that physical health just like mental health guarantees the complete state of well-being. Some mental conditions have been associated with chronic physical conditions (Bhattacharya Sambamoorthi, 2013). Chronic diseases like cancer and heart disease may cause withdrawal from social interactions and is highly associated with depression. Such conditions may also make it difficult to diagnose and assess mental health illnesses like depression according to Depression and Anxiety Issue Information (2017). Also, mental illness poses a high risk of experiencin g chronic physical conditions. Similarly, chronic physical illnesses increase the risk of developing mental ill-health. Mental fatigue particularly contributes to physical withdrawal from activities as is in the case of social anxiety disorder. While mental fatigue does not impact on the performance of the heart and/or muscles, it influences the perception of performance of different activities (Spielberg et al, 2014). In view of Georgias case, it is evident that she is mentally fatigued from the workload of her studies. This has resulted to her always being tired physically thus unable to perform her usual daily activities like early evening walks (School ofNursing Midwifery, 2017). Her perception of performance has therefore, been affected. Another relationship between physical and mental health can be seen from the examination of the connection between ones physical health and anxiety (Subramaniapillai, 2014). In this regard, mental illness as is the case of anxiety disorder brings about fear, worries and panic. This makes an individual to physically avoid particular places and also shun from participating in social activities (Versella et al, 2016). Physical health in itself influences ones mental health. Indulging in physical exercises which enhance ones mood and reduces irritability shows the positive effect of physical health on mental health (Talbott, 2012). Physical health problems increase the risk of mental illness. Depression can cause insomnia, fatigue and high sensitivity to pain resulting from abnormal functioning of neurotransmitters. It is thus rational to conclude that mental health goes hand in hand with the physical health of an individual. Personal recovery There are different ways that individuals with social anxiety disorder can manage to achieve personal recovery through reconciling physical and mental health determinants within their environment. According to Fang et al (2013), participation in regular body exercise is highly recommended in improving ones mental health. Exercise helps the body to release hormones like endorphins and serotonin which reduces anxiety and depression. Therefore, Georgia is highly advised to take up daily exercise routines in order to release the pressures of class work load that will cause her to relax and be able to do more and better in her studies. Secondly, according to Singh (2016), a healthy diet increases brain function and provides energy that reduces the possibility of developing fatigue. It has been shown that diets with low nutrients tend to increase the risk of anxiety and depression. Since proper dieting is advised, skipping meals should be discouraged as it contributes to fatigue and irrita bility due to surges in stress hormones (Singh, 2016). Georgia lives alone in a flat and this poses a high risk of unhealthy eating. It makes her more likely to eat snacks which are particularly low on balanced nutrient content. It is therefore, important that she gets support from friends and family members in order to always maintain healthy eating habits. Thirdly, personal recovery for anxiety disorder as well as other mental health cases requires individuals to have a normal uninterrupted sleep (Asakura, 2015). Lack of enough sleep is often associated with stress, anxiety and depression as seen in Georgias case. In cases of insomnia, one is advised to relax before bed, lower the intake of caffeine or have a strict sleep schedule(Singh, 2016).In Georgias case, it is advised that she should keep a strict sleep schedule for her to relax more and reduce the fatigue. She should also seek foe medication in order to be treated for insomnia. Lastly, it is advisable to always reach out to friends and relatives for social support according to Fang et al (2013). Georgia has very low support which has made her more vulnerable to mental illness. Her parents reside in the Country which is far away from her while her brother is in London. She therefore lacks direct family care and thus brings a feeling of loneliness. She has also declined invitations from friends which show lack of support from the friends (School ofNursing Midwifery, 2017). She therefore should be encouraged to reach out to her friends and be able to communicate with them on her status and reduce the feeling of loneliness and dealing with the situation alone. These approaches will be important in solving her mental and physical ill-health. Recognizing and Responding to Mental Health Condition Mental health illnesses are best diagnosed by a psychiatrist in collaboration with other healthcare professionals. Since there are no definitive physical tests in the diagnosis of mental disorders, symptoms and medical history are used to diagnose them (Weeks et al, 2013). Mental disorders vary in severity and causes thus determining the ways of managing them. Mild disorders can easily be managed by understanding and providing support to the patient (Fang et al, 2013).The more severe ones require the attention of psychologists or psychiatrists. Medications like antidepressants can be used in the treatment of mental illnesses as they reduce anxiety and depression (Ehrlich Dannapfel, 2017).Psychotherapy is also necessary to address the emotional responses to the mental disorder. Cognitive behavior therapy is also advised; which teaches the patient to recognize triggers of anxiety and change the thought patterns in order to avoid panic (Asakura, 2015). The specialists should come up with a mental health care plan. In order to communicate with mentally ill patients it is important to give them time in order express themselves, and listen to all the verbal and non-verbal ques (Greener, 2014). Therefore, the patient or the care-giver should ensure that the diagnosis of the disorder is properly done, know the professional support network, have the relevant information about the disorder and the treatment, know how to give self-care and finally know the danger signs and the relevant responses.It would be best if Georgia would seek family support to manage the anxiety disorder with the help of mental health professionals. Implications of practice of health professionals Implications for practice and/or conclusions that can be drawn from this analysis for health professionals in this field include majorly, the need to adhere to legal and ethical guidelines. These include policy pieces which are aimed at protecting majorly the patient and the health professional as well. One of the ethical and legal obligations is the need for confidentiality in the provision of care. Patients have the right talk to health professionals in complete confidence(Kress et al, 2013). The health professionals can only breach confidence in very few circumstances, especially when the patient poses as a threat to his/ her surroundings. The information of the patient may be given to another person, especially their care givers, with the consent of the patient. For the case of Georgia, her parents can be given information on her health status with her permission. The consent according to (Greener, 2014) should be documented clearly and any changes in its consent should be noted. Secondly, there is the right to treatment for everyone including those with mental disorders. Every mental illness patient has the right to access and get assessed, diagnosed and treated. The health professionals have the duty of giving treatment that will be helpful to the patient. Further, informed consent in the provision of mental health is an imperative issue for professional in this field (Kress et al, 2013). It is the duty of the mental health professional to provide information to the patient regarding the disorder, the treatment options and possible side effect of the options (Asakura, 2015). This helps the patient to give their medical background and also make informed decisions regarding management and treatment of the disorder. It is very important that Georgia is informed of her disorder and the causative agents and well advised on how to manage it. The health professionals should also be made aware of the medical history and family background of Georgia given that the mother has a history with anxiety disorder. In conclusion, mental health has a significant association with physical health and the two should not be treated as separate entities but rather use integrated approaches. Mental health illness can be managed and treated successfully not overlooking the physical health challenges. Georgias case can be managed through social and medical support to avoid severity of the case. References Asakura, S. (2015). Diagnosis and Clinical Evaluation of Social Anxiety Disorder.Anxiety Disorder Research, 7(1), pp.4-17. Bhattacharya, R. and Sambamoorthi, U. (2013). Excess risk of chronic physical conditions associated with obesity and common mental health conditions: Depression and/or anxiety. Value in Health, 16(3), p.A58. Depression and Anxiety Issue Information. (2017).Depression and Anxiety, 34(5), pp.383-389. Ehrlich, C. and Dannapfel, P. (2017). Shared decision making: People with severe mental illness experiences of involvement in the care of their physical health.Mental Health Prevention, 5, pp.21-26. Fang, A., Sawyer, A., Aderka, I. and Hofmann, S. (2013). Psychological treatment of social anxiety disorder improves body dysmorphic concerns. Journal of Anxiety Disorders, 27(7), pp.684-691. Gambini, O. (2016). Psychiatric disorders associated with 22q11.2 deletion syndrome. Mental Illness, 8(1). Greener, M. (2014). Managing generalised anxiety disorder.British Journal of Mental Health Nursing, 3(3), pp.100-104. Kress, V., Hoffman, R., Adamson, N. and Eriksen, K. (2013). Informed Consent, Confidentiality, and Diagnosing: Ethical Guidelines for Counselor Practice. Journal of Mental Health Counseling, 35(1), pp.15-28. Singh, K. (2016). Nutrient and Stress Management. Journal of Nutrition Food Sciences, 6(4). Spielberg, J., Miller, G., Warren, S., Sutton, B., Banich, M. and Heller, W. (2014). Trans-diagnostic Dimensions Of Anxiety And Depression Moderate Motivation-Related Brain Networks During Goal Maintenance. Depression and Anxiety, 31(10), pp.805-813. Subramaniapillai, M. (2014). Physical Activity and Mental Health.Mental Health and Physical Activity, 7(2), pp.87-88. Talbott, J. (2012). Associations between Physical Activity and Physical and Mental HealthA HUNT 3 Study. Yearbook of Psychiatry and Applied Mental Health, 2012, pp.257-258. Uher, R., Payne, J., Pavlova, B. and Perlis, R. (2013). MAJOR DEPRESSIVE DISORDER IN DSM-5: IMPLICATIONS FOR CLINICAL PRACTICE AND RESEARCH OF CHANGES FROM DSM-IV.Depression and Anxiety, 31(6), pp.459-471. Versella, M., Potter, C. and Heimberg, R. (2016). Socially-relevant Panic Symptoms in Social Anxiety Disorder. Journal of Experimental Psychopathology. Weeks, J., Howell, A. and Goldin, P. (2013). GAZE AVOIDANCE IN SOCIAL ANXIETY DISORDER.Depression and Anxiety, 30(8), pp.749-756. WHO (2014). Mental health: A State Of Well-Being. Retrieved on 22/9/2017 at https://www.who.int/features/factfiles/mental_health/en/ Wright, K., Lebell, M. and Carleton, R. (2016). Intolerance of uncertainty, anxiety sensitivity, health anxiety, and anxiety disorder symptoms in youth. Journal of Anxiety Disorders, 41, pp.35-42. Ying, S. (2015). Research on the Effectiveness of Exercise Therapy Treating Mental Illness. The Open Cybernetics Systemics Journal, 9(1), pp.1539-1543.